Gene Expression & Mutation Phenomena-Based Lesson: The Tale of Two Mice: Identical DNA, Opposite Lives via Epigenetic Methylation Teacher Discussion Guide | Biology II | Grades 9–12

This is the teacher discussion guide, with lesson flow, facilitation questions, anticipated student ideas and model explanations for leading the class discussion for the Phenomena-Based Lesson in the Biology II (grades 9–12) chapter Gene Expression & Mutation, built around the phenomenon The Tale of Two Mice: Identical DNA, Opposite Lives via Epigenetic Methylation. It is sold separately from the other two parts of the set.

Complete the set: Gene Expression & Mutation Phenomena-Based Lesson: The Tale of Two Mice: Identical DNA, Opposite Lives via Epigenetic Methylation Presentation; Gene Expression & Mutation Phenomena-Based Lesson: The Tale of Two Mice: Identical DNA, Opposite Lives via Epigenetic Methylation Student Response Sheet. Scaffolded version: Gene Expression & Mutation Scaffolded Phenomena-Based Lesson: The Tale of Two Mice: Identical DNA, Opposite Lives via Epigenetic Methylation Teacher Discussion Guide.

Sections: NGSS Dimension; Specific Performance Expectation & Dimensional Alignment; Slides; Segment; Focus Activity & Instructional Goal; Anchoring Driving Question (student Sensemaking):; Teacher Script (read Aloud To Introduce Phenomenon):; Talk Move Category. Sample item: “• Tier 1 (Observation): What physical and metabolic traits distinguish the yellow agouti mouse from the brown agouti mouse despite identical DNA sequences?”

What's inside: Teacher Discussion Guide (editable .docx + PDF, about 2,224 words, 8 pages); answer key / model answers for the teacher.

Standards: NGSS High School Life Science (HS-LS) disciplinary core ideas and the science practices of analyzing data and constructing explanations.

Resource type: Phenomena-Based Lesson – Teacher Discussion Guide. Format: editable Microsoft Word file plus a ready-to-print PDF.

Classroom use: Open with the phenomenon slide show, let students record ideas on the response sheet, and lead the discussion with the teacher guide. Built for Biology II, grades 9–12.

Format note: These files are delivered in Microsoft Office formats (Word and/or PowerPoint). If you open a worksheet that includes tables in Apple Pages or another non-Microsoft app, table formatting may not display correctly. For best results, use Microsoft Word or PowerPoint (or upload the file to Google Docs). If you run into any formatting issues, contact us and we can send a PDF version.